By
Howard
J.
Worman,
M. D.
Autoimmune
hepatitis-Cis
a
condition
in which
the
patient's
own
immune
systems
attacks
the
liver
causing
inflammation
and
liver
cell
death.
The
condition
is
chronic
and
progressive.
Although
the
disease
is
chronic,
many
patients
with
autoimmune
hepatitis
present
acutely
ill with
jaundice,
fever
and
sometimes
symptoms
of
severe
hepatic
dysfunction,
a
picture
that
resembles
acute
hepatitis.
Distinctive
Clinical
Features.
Patients
with
autoimmune
hepatitis
and PBC
were
distinguished
from
those
with
definite
autoimmune
hepatitis
by
having
lower
serum
levels
of
immunoglobulin
G,
higher
serum
concentrations
of
immunoglobulin
M, and a
lower
occurrence
of SMA .
Importantly,
these
patients
were
indistinguishable
from
those
with
definite
autoimmune
hepatitis
by serum
aspartate
aminotransferase,
bilirubin,
alkaline
phosphatase,
and
-globulin
concentrations
.
Incidence
Autoimmune
hepatitis
usually
occurs
in women
(70 %)
between
the ages
of 15
and 40.
Although
the term
"lupoid"
hepatitis
was
originally
used to
describe
this
disease,
patients
with
systemic
lupus
erythematosus
do not
have an
increased
incidence
of
autoimmune
hepatitis
and the
two
diseases
are
distint
entities.
Labs
Patients
usually
present
with
evidence
of
moderate
to
severe
hepatitis
with
elevated
serum
ALT and
AST
activities
in the
setting
of
normal
to
marginally
elevated
alkaline
phosphatase
and
gamma-glutamyltranspeptidase
activities.
Symptoms
The
patient
will
sometimes
present
with
jaundice,
fever
and
right
upper
quadrant
pain and
occasionally
systemic
symptoms
such as
arthralgias,
myalgias,
polyserositits
and
thrombocytopenia.
Some
patients
will
present
with
mild
liver
dysfunction
and have
only
laboratory
abnormalities
as their
initial
presentation.
Others
will
present
with
severe
hepatic
dysfunction.
Risk
Autoimmune
hepatitis
should
be
suspected
in any
young
patient
with
hepatitis,
especially
those
with
risk
factors
for
alcoholic,
drug,
metabolic
or viral
etiologies.
Tests
Serum
protein
electrophoresis
and
testing
for
autoantibodies
are of
central
importance
in the
diagnosis
of
autoimmune
hepatitis.
Patients
with one
subtype
of
autoimmune
hepatitis
have
serum
gamma-globulin
concentrations
more
than
twice
normal
and
sometimes
antinuclear
antibodies
and/or
anti-smooth
muscle
(anti-actin)
antibodies.
Patients
with
another
subtype
may have
normal
or only
slightly
elevated
serum
gamma-globulin
concentrations
but will
have
antibodies
against
a
particular
cytochrome
p450
isoenzyme
that are
called
anti-LKM
(liver
kidney
microsome).
How is
the
Hepatitis
caused
Patients
in whom
a
diagnosis
of
autoimmune
hepatitis
is
suspected
may not
have a
liver
biopsy
as
chances
of
bleeding
are
excessive.
TreatmentFollowing
are the
alternative
treatments:
Lycopodium
is a
Homeopathic
remedy
used in
Hepatitis
and is
very
useful
in
prevention
and
treatment
of all
forms of
hepatitis
including
hepatitis
C,
In
Natural
treatments
the
spice
Saffron
full of
antibodies
is a
excellent
treatment.
Full
remedy
in our
e-book.
Prevention:
Hepatitis
can be
triggered
by
celiac
disease
so ,
avoid
wheat
grain,
Avoid
excessive
alcohol,
exposure
to
BPA,
one of
the
biggest
cause is
Aflatoxin
and
contaminated
foods
need to
be
avoided.
Hepatitis
-C has
been
reversed
by above
methods
in three
weeks
and many
others
have
used
Hulda-Clark
zappers
successfully. |