What is IVIG
or Intra Venous Immunoglobulin
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1. What is
IVIG or Intravenous Immune Globulin?
IVIg is a collection of antibodies called IgG or Immuno
IgG is a naturally made by plasma cells
in our body, IgG antibody, also known as an immunoglobulin-G is a
large Y-shaped protein used by the immune system to neutralize
foreign objects like viruses and bacteria.
IVIg is formed by
taking IgG antibodies from about 20,000 donors and mixing them
together. infusion of IVIg has proven effective in immune
deficiency disorders, including nearly all autoimmune conditions
like CIDP and GBS.
The sooner you treat the patient with IVIg the better the results.
There is a short window of opportunity usually within the first 18
months after the diagnosis. Treatment with IVIg within the window
period is likely to halt the progress of the disease. Example is
Kawasaki disease, once IVIg is used full recovery follows.
After being exposed to toxins and poisonous
chemicals including carbon monoxide the body's immune system may
mount a attack on the body. This autoimmune attack can be halted by
any anti-inflammatory treatment including IVIg.
2. How does
IVIg is used in immune deficiency
where the body does not make enough antibodies, IVIG supplies
them. For autoimmune disorders like GBS & CIDP, there is a abnormal
antibody (autoantibody) being formed which is inactivated by IVIG.
Patients with autoimmune disorders like CIDP also
are deficient in antiidotype antibodies. IVIG supplies them.
Antiidotype antibodies are normal antibodies which are produced in
the absence of any antigen. They are capable of inactivating many
different types of antigens.
3. How long
does it take to a IVIG treatment to have a effect?
After IVIg is infused patients may see a response in
24- 48 hours. Some patients will have to wait 3-4 weeks to see an
effect. In a few no effect may be seen. If 4-5 cycles of IVIg do not
show any response then try a different approach like add intravenous
steroids and antibiotics.
Everyone is slightly different as it depends on how
long has the disease process been going on. The sooner one treats it
the disease the faster the response.
4. Why is IVIG
IVIg is obtained from plasma donors
who are paid then the plasma is sent to a processing centers
for mixing, antibody removal, chemical treatment and filtration to
remove viruses. This is followed by the products to be
freeze dried. All this ends up for IVIG to be priced at $ 48 to $ 60
a gram (cost price of IVIg). A single infusion of IVIg may cost
about $3000 for a child to $10,000 for adults. For a child the cost
is lower as a small IVIg dose is used. If you have insurance you
will see the cost of infusion may go to 100,000.
The cost of IVIg in India & Pakistan $46 a gram,
lower prices are found in China where the manufacturer will see IVIg
for $10- a gram. This price has doubled in the last year. A pharmacy in Bangladesh Dhaka sells the cheapest IVIg 5 dollars a bottle of Baygam made in Germany. At cidpusa.org we
ordered and tested this IVIg was 100% authentic. (infusions were
done in Dhaka testing in Lahore). FDA does not allow foreign IVIg
5. How is IVIG
IVIG is mixed in a bag and a tube runs from it to a
vein usually in the arm. The recommended way to infuse includes a
pump. Usually IVIg is infused at a rate of 100 cc/ hour to 200 cc/
The rate of IVIg is reduced for any
problems such as headaches, rash, fatigue, hypertension or
hypotension. For an adult's IVIg infusion is usually given
over 5 to 6 hours. Dr Dalakas mentioned in his
study that precise control of IVIG infusion is required.
6. What are
the common side effects OF IVIG?
IVIg at times causes patients to get a
headache, which is more common in females with a history of
Migraines. after IVIg infusion some Patients may experience fatigue
similar to getting a Flu, which is due to antibodies interaction.
IVIg may also cause to patients get a rash and doctors
recommended they take Benadryl or even steroids to avoid this.
Remember their are a lot of antibodies and some may result in odd
reactions. Kidney failure may result after IVIg if less fluids are
given. Stroke or heart attack can happen after IVIg if the IVIg
solution is pumped in at a fast rate.
A severe headache with a stiff neck after IVIg may
be due to aseptic meningitis.
Variation in blood pressure, shortness of breath,
back pain can also be seen after IVIg infusion. Serious conditions
like encephalitis, myocarditis have been seen.
7. How can one
reduce the side effects of IVIG?
Remember to drink eight glasses of water a day for
hydration before starting the IVIg treatment and continuing this a
month after the last IVIg infusion. Some doctors recommend to take a
baby aspirin to prevent thrombophelebitis. Patients need to check
with their doctors if they can use aspirin and should not take
this if they are on coumadine or have bleeding disorders or if they
have a history of gastric ulcers. Doctors use Premedication
to help reduce side effects. Some recommend that one should take
Tylenol or other NSAID for prevention of headaches and pains. Use a
benadryl capsule for a rash and even to relax during the treatment.
Using low dose prednisone will reduce side effects like headaches.
8. Where is
the IVIG treatment given?
IVIg can be given at home, in a doctors clinic or a
hospital outpatient unit. Some patients have even taken IVIg at
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IgM, IgA, IgD are also present in IVIg. If a person is low is
any of these immunoglobulin's after IVIg infusion their level will
rise up. There is no way at present to make IVIg free of IgE, IgM, IgA, IgD .
We can help you get IgIv
infusions in USA, Canada, Australia and UK.
Many infusion providers in california among them crescent biofusion
kaba or kabafusion. These companies all came out of crescent then
came biofusion and kaba fusion.
cidpusa will refer
you for IGIV infusion in USA, UK, Australia and Canada private or
suppliers of IgIV are Apria, Corum, Crescent,
Biofusion, Walgreen, KabaFusion