blue hands &
then read on.
What is Takayasu's
In 1908, a ophthalmologist Dr. Mikoto Takayasu reported ocular changes in a 21 year old Japanese woman. Cases presented through the years put together the criteria for classifications and presentation of Takayasu's Arteritis. By 1975, the disease was named Takayasu's Arteritis and is a Vasculitis affecting large blood vessels.
Arteritis is a , chronic, inflammatory disease affecting larger
arteries like aorta and its branches. The subclavian,
renal, carotid, and the ascending aorta arteries can be
Takayasu's Arteritis affects more females than males and usually begins in the 2nd or 3rd decade of life. TA is occasionally called "pulseless disease" because there is difficulty in detecting peripheral pulses that sometimes occurs as a result of the vascular narrowing. It is also common for a patient to exhibit vascular bruits, and symptoms of their arterial involvement. The cause of TA is autoimmune
Symptoms may include: headaches, dizziness, fainting, low grade fever, muscle aches, weight loss, circulatory deficit, vision problems, angina, joint pain, claudication, malaise, hypertension, night sweats, stroke, fatigue, stiffness. Symptoms of TIA like weakness or numbness on one side, migraine phenomena like flickering lights in the eye with or without headaches are present.
Young girls with headaches
should get a ESR and every young girl with a reduced pulse
should get a ESR too.
It should be routine test to
do a ESR and CRP in every female patient.
Making the diagnosis of TA can be extremely difficult.
The disease is present for many years before detection , so it can "smolder" in the walls of large blood vessels for many years, causing only minor symptoms, until major complication results. This can eventually lead to occlusion, complete closing of the vessels. There can be major complications resulting, in the dilation of the aorta with stretching of the aortic valve in the heart, resulting in severe valve damage, and critically reduced blood flow to an arm or leg. In addition, a stroke caused by high blood pressure of the blood vessels going to the brain, renal failure, and many other serious afflictions are also possible.
Diagnosis is made by a elevated sed rate (ESR) is usually 50-60 plus clinical findings of a reduced pulse. The patients have cold blue hands, women will not have the usual hand softness. They have tiredness and fatigue, one patient had not gone to scholl for a year. Another marriend young woman had seen a neurologist for headaches. The disease was only diagnosed after her pregnancy when she became stiff and was seen walking slowly. The person suffering from the disease cannot sense the problem but others do.
At cidpusa we have not done
any further testing other then ESR. The MRI angio provides
abnormalities in the following: angiography (especially of aorta
and branches), blood tests :sed rate (ESR), c-reactive protein,
Albumin, Globulin and Fibrinogen, complete blood count, biopsy
(rarely done do not recommend), chest X-ray, ultrasound, arteriographic
blood pressure measurements, magnetic resonance imaging studies,
Diagnosis is simple if you check pulses and get a ESR. Otherwise difficult due to the erratic course of the disease.
Delay in diagnosis is common even when working with physicians experienced in vascular disease.
If you have Takayasu the doctor treating you will focus
on treating the cause as well as the condition. You may be
advised to drink more fluid (increase your fluid intake) and to
avoid certain drinks such as alcohol and diet cola drinks with a
lot of sodium chloride (salt) and/or potassium in them. Your
diet should be controlled carefully. Your GP or dietician will
give you advice on eating protein and controlling the your
intake of processed food, grain and table salt. Your blood ESR
will be regularly reviewed to ensure that levels comes below 20
are at the right level and that the amount of fluid in your diet
is correct. Your treatment may include corticosteroids and a
drug called cyclophosphamide. Other drugs used will relate to
the underlying cause of the condition and the body’s response to
Takayasu . We used Vibramycine/ doxycycline please see our
e.book for full details of this protocol. Follow our diet on the
Treating high blood pressure:
High blood pressure damages the kidney further and causes
other health problems. Your blood pressure will be monitored by
the doctor treating you and may need to take drugs such as ACE (Angiotensin
Converting Enzyme) inhibitors which relax the blood vessels and
reduce the workload of the heart.
Treating chronic kidney disease or kidney failure:
In cases of chronic kidney disease or kidney failure, kidney
dialysis (using a machine to do the kidneys’ job of removing
waste products from the body) or a kidney transplant will be
Possible complications vary according to the type of
Takayasu but can include:
High blood pressure: This is a
common complication of .Takayasu, because the kidneys
help control the blood pressure in the body. Many people
with .Takayasu are prescribed drugs to lower blood
pressure. It is important to take these to protect the
kidneys against further damage and also to reduce the
risks of heart disease and stroke. If blood pressure is
untreated it can lead to heart failure and fluid in the
lungs (pulmonary oedema).
Disease in other internal organs: In
most patients, .Takayasu affects only the kidneys.
However, in some cases, the immune system that damages
the kidneys can also affect other parts of the body, for
example giving a blotchy red rash on the skin or pain in
the joints. Discuss any symptoms you may have with your
doctor to see if they could be related to .Takayasu. If
you develop a blotchy red skin rash you should see your
Kidney disease or kidney failure:
This is rare, but .Takayasu can cause so much damage to
the kidneys that they fail completely.