7) Vitamin E as d-alpha Tocopherol acetate of d-alpha Tocopherol acid succinate. The latter is more practical since it is a pure form. Deficiency has also been shown to produce demyelinization and distortion of the axon pattern in the spinal cord, giving rise to hypalgesia and progressive paresis. Fatal massive liver necrosis occurs in animals maintained on diets low in vitamin E and sulfur-containing amino acids. 800 international units before meals and bedtime must be adhered to in this treatment.

8) Crude liver: This substance contains factors still unknown but essential in metabolism. patients with pernicious anemia often show neurological involvement, and are tremendously benefitted by liver injections which, of course, contain vitamin B12. Degenerative changes brought on by other factors, therefore, can also be benefitted by daily injections of crude liver.

9) Adenosine-5-Monophosphoric acid: One of the purine bases occurring in muscle is adenne. It, along with other purines, exists in various forms. Adenosine polyphosphate is of primary interest in this discussion. The basic structure is adenosine, adenine-9-riboside. This is esterified with phosphoric acid at the 5-position of the ribofuranose, to form adenosine-5-phosphoric acid, also known as adenosinemonophosphate (AMP). Inosinic acid I a commonly-occurring breakdown product of AMP, formed by deamination in muscle extract.  By adding this to our treatment, we enhance all chemistry dealing with cell metabolism.

10) Choline: Choline is a structural component of fat and nerve tissue, thus has a strong relationship to the phospholipids and to its acetyl ester. Acetylcholine plays an important role in the humoral transmission of parasympathetic and other nerve impulses to effector organs. It also plays a part in transmethylation. Choline serves as a methylating agent in the physiological process – guanidoacetic acid to creatine. We give 700mg to 1400mg after each meal and at bed hour.

11) Lecithin: Lecithin is the glyceryl ester of a pair of fatty acids and a substituted phosphoric acid group attached to a choline radical. “Choline” is one of the products of lecithin, representing about 15% of the molecule. Lecithin placed in water and observed under the microscope, will diffuse out, forming long, curving strands (myelin forms). The hydrophilic nature of the lecithin molecule play an important part in the structure and properties of cell membranes.

12) Magnesium: 100mg. after each meal to supply additional ions for muscle activity. It is an enzyme activator.

13) Calcium Gluconate (10 grain tablets): We give two tablets after each meal and at bed hour to supplement dietary intake for muscle activity. At times, this is given intravenously, one gram twice weekly.

14) Calcium panthotenate: The physiologically active form of pantothenic acid is coenyzme A. Its acetyl derivative (acetyl CoA) is synonymous with active acetate. Metabolic transformations are very complex and involve numerous enzymes and coenzymes. Coenzyme A participates in the acetylation of amines. The pantothenic cid coenzyme plays a vital role in carbohydrate metabolism and acetyl transfer also occurs in the metabolism of fatty acids. We give 200 mg. after each meal and at bed hour.

15) Aminoacetic acid (glycine): Glycine  Rapport and Katz have shown that when glycine is added to perfused muscle, the oxygen absorption is 40% higher than otherwise, indicating that the presence of this amino acid stimulates the combustion of other tissue constituents. To the body in general, glycine is no doubt most important because of its wide adaptability in the detoxicating process of the body. More than one hundred substances, when fed, are joined in the body with glycine. In the deamination of glycine, three products will be formed: ammonia, carbon dioxide and water.

16) Make certain that the hemoglobin is at least 13 grams.

17) High protein diet with two to three eggs or breakfast.

18) One Theragram-M cap. daily for trace minerals.

19) Dantrium has value for relieving intentional tremor and Symmetrel for relieving stiffness in Multiple Sclerosis. Dose must be individualized.

20) Zinc gluconate: 10 mg. three times each day has some value in Myasthenia Gravis. Take several hours after vitamin B2.

This treatment works so dramatically in Myasthenia Gravis, that should a given patient’s physician refuse to administer this schedule, I have this recommendation: One gram thiamin hydrochloride one hour before meals and at bed hour, and during the night if awake. Niacin taken at the same time, and in amounts sufficient to produce a good body flush. Two hundred mg. calcium pantothenate and 100mg pyridoxine before meals and at bed hour. Ten grams ascorbic acid, taken in divided doses. Amino acetic acid: one heaping tablespoon in a glass of milk, four times each day. Naturally, the full schedule will afford more dramatic response.

For a long time, it has seemed to me that virus bodies might have the potential to alter their protein coat, and therefore their dimension, and become annother virus for another disease. In our long practice, we would see, as I am certain may of you have, chicken pox just before Thanksgiving, mumps by Christmas, red measles in the Spring, and polio or a virus mimicking polio in the Summer. German measles, virus colds, and virus pneumonitis just about any time.

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