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What is IVIG 20 Facts
1. What is
IVIG or Intravenous Immune Globulin?
IVIg is a collection of Y shaped antibodies called IgG as
shown in the above cartoon.
IVIg is a pooled plasma product
formed by taking antibodies from donors and mixing them together.
IVIg has proven effective in several immune system disorders,CIDP
,MS, stiff person syndrome and GBS.
The sooner you can treat the patient with IVIg the better the
results. There is a window of opportunity usually within the first
18 months during which IVIg administration is ideal. The longer you
wait to treat with IVIg the longer it will take for IVIg to work.
After being exposed to toxins and poisonous
chemicals including carbon monoxide the body's immune system may
mount a attack on the body. This autoimmune attack can be tamed by
2. How does
For immune deficiency where the body
does not make enough antibodies, IVIG supplies them. For
autoimmune disorders like GBS & CIDP, there is a abnormal
autoantibody being formed which is inactivated by IVIG.
Patients with autoimmune disorders like CIDP also
are deficient in antiidotype antibodies. IVIG has antiidotype
antibodies & improve the patients condition. IVIg has a higher
concentration of antiidotype antibodies.
3. How long
does it take to a IVIG treatment to have a effect?
After IVIg infusion, patients may see a response in
their disease within 24- 48 hours. Some patients will have to wait
3-4 weeks to see an effect after IVIg. In a few no effect may be
seen following IVIg infusion. If 4-5 cycles of IVIg do not show any
response then try increasing the dose of IVIG ,, most people will
respond to increase in dose, rarely a change in IVIg brand is needed
to see a responce(. The NIH recommends that if no
response is seen with IVIg infusions, then add steroids to the
Everyone is slightly different as it depends on how
long has the disease process been going on. The sooner one treats
the disease with IVIg the faster the response. No one can predict
how a particular patient will respond to IVIg.
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