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 Broccoli reverses diseases

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Sat, 31 May 2008 17:55:07
By CIDPUSA, MD.,
Broccoli Can Turn Off Prostate Cancer Genes

Broccoli reverses  Cancer  Diabetes & heart disease



- Taking a clue from a rare disorder in which the immune system destroys a patient's cancer even as it attacks the nervous system, researchers have devised a new strategy to fight breast and ovarian cancer. The scientists have engineered immune cells that target cells containing a protein found in up to 60 percent of ovarian tumors and 25 percent of breast tumors.
The engineered cells, which recognize a protein that can trigger an autoimmune response in a small percentage of patients with these cancers, attacked and killed tumor cells grown in the laboratory. “These findings have brought us right to the cutting edge of tumor immunotherapy,” said Howard Hughes Medical Institute investigator Robert Darnell, who led the research.

“These findings have brought us right to the cutting edge of tumor immunotherapy.”
Robert B. Darnell

Darnell and his colleagues theorized that they might find such antigens within the cells of people with a rare disorder known as paraneoplastic cerebellar disorder (PCD). PCD arises in patients whose tumors produce antigenic proteins usually found only in the brain. The robust immune response to these antigens can trigger killer T cells to attack not just the tumors, but also cells in the nervous system, causing neurologic degeneration.

The disorder is associated with a range of cancers, including lymphomas and lung and testicular cancers. Darnell and his colleagues studied cases in which breast and ovarian tumor cells had triggered an autoimmune attack. In these patients, neurological symptoms usually become problematic before cancer has been detected -but probably well after the immune system has first

The researchers concentrated on a tumor antigen called cdr2, which, when produced by breast and ovarian tumors, can trigger PCD. It is also made by a large proportion of breast and ovarian tumors in patients who do not develop neurological disease. The researchers screened a large library of slightly different fragments of the cdr2 protein for those that were most strongly recognized by T cells, and identified one particularly potent version called cdr2(290).

The researchers found T cells that responded to cdr2(290) in the blood of patients with PCD, confirming that they had identified a clinically relevant antigen. Darnell said the same molecule the researchers used in these studies to search for cdr(290)-responsive T cells could potentially also be used as a diagnostic in cancer patients to help guide therapy.

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