Helicobacter Pylori is a communicable bacteria that
drills its way through the stomach mucosa and attaches itself to
the inside of the epithelia or stomach lining. Our body has a
ingenious way of keeping the immune system from attacking the
food we eat. It isolates the stomach’s content so the immune
system can't see it. The body does this by coating the stomach
with a jelly-like substance and preventing antibodies from
entering through the stomach lining. The food is then digested
and enters the small intestine. If nature didn't separate the
food our immune systems would see it as a foreign intruder and
People suffering from H. Pylori have been
they took antibiotics to eradicate
Here is a recently published study.
High prevalence of sustained remission of idiopathic
thrombocytopenic purpura after Helicobacter pylori eradication:
a long-term follow-up study.
Veneri D, Department
of Medicine, Haematology, University of Verona, Verona, Italy.
We studied the effect of Helicobacter pylori (H. pylori) eradication
in 43 consecutive H. pylori-infected patients with idiopathic
thrombocytopenic purpura. H. pylori was eradicated with antibiotics
in 41 of them
(95.3%). The difference between the
mean platelet count before and after therapy was statistically
(54.3 x 10(9)/l vs. 119.1 x 10(9)/l; P <
0.001). A sustained remission was observed in 20 patients
(48.8%), after a median follow-up of 31.2 months. None of the
patients still infected by H. pylori after therapy reached normal
platelet values. The long-term follow-up confirms the efficacy of
H. pylori eradication in H. pylori-infected ITP patients.
PMID: 15823868 [PubMed - in process]
So one needs to look and
eradicate HPylori if you have ITP. "In conclusion, H pylori
infection was involved in most ITP patients older than 40 years in
Japan, and eradication therapy should be the first line of treatment
in H pylori-positive ITP patients."Int J Hematol. 2005
What about antibiotics and Neurology
1: Lancet Neurol. 2004 Dec;3(12):744-51.
The promise of minocycline in
Yong VW, Department of Neurosciences,
University of Calgary, Alberta, Canada.
The capacity of
minocycline to alleviate disease for several neurological disorders
in animals is increasingly being recognised. Indeed, that one drug
alone can attenuate the severity of disease in stroke, multiple
sclerosis, spinal-cord injury, Parkinson's disease, Huntington's
disease, and amyotrophic lateral sclerosis is astounding. In this
review, we describe the evidence for the efficacy of minocycline in
several animal models of neurological disease, discuss the
mechanisms by which minocycline affects a range of neurological
diseases with diverse causes, and introduce the emerging
investigation of minocycline in clinical neurology. The encouraging
results of minocycline in experimental neurology bode well for its
therapeutic use in human neurological diseases.
15556807 [PubMed - indexed for MEDLINE]
Ann Neurol. 2004
gadolinium-enhancing magnetic resonance imaging lesions in multiple
endocarditis in a patient with multiple sclerosis--case report]
Prystupa A, Mosiewicz J.Katedry i Kliniki Chorob Wewnetrznych
Multiple sclerosis is chronic
demyelination disease associated with complex immunological
disorders, resulting in increased susceptibility to different
infections. A case of woman, aged 40 with multiple sclerosis who was
admitted to the Internal Medicine Ward because of severe general
state, fever of seven-day duration and systolic murmur in apex area
is discussed in this paper. Clinical status and performed
diagnostics, among others; echocardiography, blood cultures,
abdominal ultrasonography, allowed to diagnose infective
endocarditis caused by Enterococcus faecalis. Antibiotics as
follows: augmentin, cefuroxim, cefotaxim and vancomycin were
administered parenterally. As a result of the treatment
normalization of temperature and complete recovery were obtained.
PMID: 15058172 [PubMed - indexed for MEDLINE]
J Phys Med Rehabil. 1995 Nov-Dec;74(6):415-8.
Role of bacterial infection in exacerbation of multiple sclerosis.
Rapp NS, Physical Medicine , William Beaumont
Hospital, Royal Oak, Michigan 48073, USA.
consecutive patients admitted to the hospital with a diagnosis of
exacerbation of multiple sclerosis were evaluated for an infectious
process. All patients received a complete blood count, urinalysis,
urine culture with susceptibility studies, blood cultures, and a
chest x-ray at the time of admission. A control group of 55 patients
carrying the diagnosis of multiple sclerosis but without symptoms of
neurologic decline were also studied. Thirty-five percent of
patients experiencing exacerbation of their disease were identified
as having a significant bacterial infection compared with 11% in the
control group with quiescent disease. These results were significant
with a P value of < 0.001. When presumptive viral and bacterial
infections diagnosed before admission were included, almost 50% of
patients could have had an exacerbation of their disease in response
to an infectious process. Bacterial infection might well play a role
in precipitating relapse in multiple sclerosis as well as
PMID: 8534384 [PubMed - indexed for
1: Neurology. 2004 Jul 13;63(1):179-80.
Improvement of a CIDP
associated with hepatitis C virus infection using antiviral therapy.
Corcia P, Barbereau D, Guennoc AM, de Toffol B, Bacq Y.Department of
Neurology, CHRU Bretonneau, Tours, France.
man with chronic inflammatory demyelinating polyneuropathy
associated with hepatitis C virus infection was treated successfully
with the combination of peginterferon-alpha-2b and ribavirin. Viral
eradication was confirmed during the 4th week of treatment and was
followed 3 weeks later by neurologic improvement. The patient
resumed normal activity 1 year after the therapy was completed.
PMID: 15249636 [PubMed - indexed for MEDLINE]
1: J Peripher Nerv
Syst. 2004 Jun;9(2):98-103.
Chronic inflammatory demyelinating
polyneuropathy after Campylobacter jejuni infection mimicking
vasculitic mononeuritis multiplex in a diabetic.
Rajabally YA, Sarasamma P, Abbott RJ.
Neurology, University Hospitals of Leicester, Royal Infirmary,
Chronic inflammatory demyelinating
polyneuropathy (CIDP) is a clinically heterogeneous disorder. Recent
reports suggest that CIDP could be more frequent in diabetics. We
report here a case of CIDP presenting as mononeuritis multiplex with
accompanying cranial nerve involvement in an insulin-dependent
diabetic who presented a preceding Campylobacter jejuni infection
and misleading skin lesions. Treatment with intravenous
immunoglobulins was successful. This case suggests that CIDP should
be considered as a potential diagnosis in all diabetics with
localized, acute or sub-acute onset, and multiple, or overlapping