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Pyridoxine B-6 deficiency,

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B- group vitamin - B-6

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Vitamin B-6 related diseases

Vitamin B6,  called pyridoxine, is a B vitamins. All B vitamins help the body convert food (carbohydrates) into fuel (glucose), which is used to produce energy. The B-complex vitamins, help the body break down fats and protein. B-complex vitamins are needed for healthy skin, hair, eyes, and liver. They help the brain  function properly.

B vitamins are water soluble, the body does not store them.

Vitamin B6 helps the body make several neurotransmitters, chemicals that carry signals from one nerve cell to another. It is needed for normal brain development and function, and helps the body make the hormones serotonin and norepinephrine, which influence mood, and melatonin, which  regulate the body clock.

 B6 helps control levels of homocysteine in the blood. Homocysteine is an amino acid that  is associated with heart disease. Body needs B6 in order to absorb vitamin B12 and to make red blood cells and cells of the immune system.

It is rare to have a significant deficiency of B6, although studies indicate many people may be mildly deficient, especially children and the elderly. Certain medications can also cause low levels of B6 in the body. Symptoms of serious deficiency include:

Heart disease

 B6  affects heart disease. If  B6 is low in diet then a higher risk of heart disease. happens. B6 plays a role in lowering levels of homocysteine in the blood.

Nausea and vomiting during pregnancy (morning sickness)

Studies, found that a daily dose of 30 mg of B6 may helps reduce morning sickness.

Age-related macular degeneration (AMD)

One large study found that women who took 50 mg of vitamin B6 daily, along with 1,000 mcg of cyanocobalamin (vitamin B12) and 2,500 mcg of folic acid, reduced their risk of developing AMD, an eye disease that can cause vision loss.

Depression

Vitamin B6 helps your body make serotonin, a chemical that influences mood. Low levels of serotonin are associated with depression.

Premenstrual syndrome (PMS)

Although some studies show that vitamin B6 may help improve PMS symptoms, most of these studies were poorly designed. Studies that were well designed found no benefit. Until more research is done, talk with your doctor about whether taking B6 is right for you. Some people who believe B6 is effective for PMS say it may take up to 3 months to see a noticeable change.

Carpal tunnel syndrome

Early studies suggested that B6 might help reduce inflammation and symptoms of carpal tunnel syndrome, however, most well-designed studies have found no such link.

Rheumatoid arthritis (RA)

Low levels of vitamin B6 have been associated with RA. Some studies also suggest that people with RA may need more vitamin B6 than healthy people because chronic inflammation may lower B6 levels. Eating a healthy, balanced diet, and taking a multivitamin is a good idea for anyone who has a chronic illness, such as RA. Talk to your doctor before taking B6 supplements.

Tardive dyskinesia

A few small studies have found that vitamin B6 may improve symptoms of tardive dyskinesia compared to placebo. Tardive dyskinesia is a side effect of long-term use of antipsychotic drugs, and involves involuntary movement of muscles, such as in the tongue, lips, face and jaw, arms, legs, fingers, or toes.

Epilepsy

In majotity of children and adults B-6 can stop epilepsy.

Neuropathy carpal tunnel

In many people neuropathy and carpal tunnel syndrome can be helped by B-6.