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  Discussion

       The results presented demonstrate the rate of efficacy of CsCl in cancer therapy.  The total 50 cancer cases studied show an impressive 50% survival rate.  This confirms the work of Messiha reported in these proceedings showing that the higher the dose it is, the more effective it seems to be.   The autopsy obtained from the patient whose death was  attributed to traumatic fracture of the neck, indicated that cancer had been initially further advanced resulting in bone destruction.  However, the absence of cancer after the massive CsCl dose used in this case is demonstrable of the Cs-therapy.  It appears that both dosage, i.e., as much as 30 grams/day and route of drug administration, i.e., nasogastric pathway, might have contributed  to the patients  rapid recovery.  It should be noted, however, that CsCl dose regimens should not exceed 20 to 40 grams due to side effects, mainly nausea, and diarrhea.  The authors personal experience with CsCl after an acute dose of 40 grams CsCl indicate that extensive nausea and parethesia around the mouth are the major side effects.  This is probably due to K depletion.  The usual dose used in the clinic ranges from 2 to 3 grams given by mouth 3 times daily.  At a later time, at which time there is no indication of cancer presence, the CsCl dosage will be reduced to a preventative dose between .5 and 1 gram a day.

     The lymphoma case presented shows that CsCl efficiently reduced massive enlargements of spleen and liver as well as maximal ascites, causing an abdominal configuration of a tight, hard hemisphere, to almost normalize after 3 months of therapy.  This period of time was required to eliminate such a massive volume resulting in the reduction of the body weight noted.

     The clinical efficacy of CsCl high pH metabolic therapy is best demonstrated by a recent case of primary liver cancer (not included in the 50 cases reported in this study).  The patient was a 39 year old female teacher who was terminal.  She was brought on a stretcher on April 25, 1984 with a large liver tumor extending approximately 3 cm below the umbilical level.  The treatment was then immediately instituted.  This consisted of administration of CsCl, Beta-carotene, Vitamin C, Zn, Se, Mn, Cr, and K salts by the oral route in addition to a concomitant massive IV doses of ascorbate, K, Mg, Zn, Cn, Mn, Cr salts, B complex vitamins, folic acid, DMSO and heparin.  After 5 consecutive treatment regimens EDTA was introduced to the therapy and the minerals present in the solution were discontinued.  On May 10, 1984, the patient was discharged, returned home walking without assistance and displaying a smile on her face.  The liver tumor had shrunk to 5 cm above the umbilicus.   The determination of alphafetoprotein (AFP), a specific marker for liver cancer, rare embronal cancer and teratomas, decreased from the unusually high value of 39,000 units, compared to normal levels of 13 units, measured before initiation of Cs-therapy, to 5000 units obtained on the last day of treatment.

    The mechanism of action of Cs in cancer has been little studied.  Both Cs+ and Rb+ can specifically enter the cancer cells and embryonic cells, but not normal adult cells has been demonstrated by Brewer.  The cancer cells contain high amounts of hydrogen ions rendering them acidic and they also contain high Na+ levels than found in normal cells.  If Cs+ or Rb+ can enter the cancer cells then the pH increases from as low as 5.5 to over pH 7.0.  At a pH of 7.6 the cancer cell division will stop, at a pH of 8.0 to 8.5 the lifespan of it is considerably shortened (only hours).  In one case, the author has observed the shrinkage of metastases of breast cancer after one hour of Cs-treatment.  Two days later wrinkles of the skin appeared where the tumor was present.  In another case of a colon cancer with massive metastasis, of massive infiltration of the abdominal wall, liver and other tissues, seemed to have been  reduced  within 24 hours and continuing rapidly until the demise of the patient on the 14th day of the Cs-treatment.

     continued to uric acid levels